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Assessing the effectiveness of healthy weight interventions in the early years of childhood: a systematic review and meta-analysis of evidence from high-income countries - International Journal of Obesity
5+ hour, 22+ min ago (1777+ words) International Journal of Obesity (2026)Cite this article PRISMA flow diagram of the records identified, screened and included in the systematic review. Three studies measured percentage body fat (ES=4) and were included in a meta-analysis [40, 54, 66]. Results suggested an effect of interventions…...
Direct and indirect parental genetic effects on offspring susceptibility to internalizing problems across development - Nature Mental Health
32+ min ago (1709+ words) Nature Mental Health (2026)Cite this article only $6. 58 per issue Friedrich, M. J. Depression is the leading cause of disability around the world. JAMA 317, 1517 (2017). Bernaras, E. , Jaureguizar, J. & Garaigordobil, M. Child and adolescent depression: a review of theories, evaluation instruments, prevention programs, and treatments. Front. Psychol....
Precision genome editing with DNA base editors - Nature Reviews Methods Primers
1+ hour, 2+ min ago (1775+ words) Receive 1 digital issues and online access to articles only $119. 00 per issue Komor, A. C. , Badran, A. H. & Liu, D. R. Editing the genome without double-stranded DNA breaks. ACS Chem. Biol. 13, 383388 (2018). Anzalone, A. V. , Koblan, L. W. & Liu, D. R. Genome editing with CRISPRCas nucleases, base editors, transposases and prime editors. Nat. Biotechnol....
HECT ubiquitin ligases as regulators of inflammatory signalling - Cell Death & Differentiation
12+ hour, 33+ min ago (1843+ words) Cell Death & Differentiation (2026)Cite this article HECT E3 ligases fine-tune inflammatory signalling rather than acting as simple on/off switches. NEDD4-family E3s regulate caspases, gasdermins, Smads and inflammasomes at multiple checkpoints to shape cell death and inflammation. HERC E3s link interferon and nucleic…...
Complete inhibition of "-tryptase by tetramer dissociation and active site allostery due to a single antibody residue - Nature Communications
1+ hour, 28+ min ago (1734+ words) While E82. AS is a potent inhibitor of human "-tryptase, it still contains rabbit variable domain sequences. Prior to testing this antibody in the clinic, full humanization would be required for developing it as a therapeutic to avoid any unwanted immunogenicity....
Development of a clinically viable MRGPRX4 inverse agonist for cholestatic itch treatment - Nature Chemical Biology
1+ hour, 38+ min ago (1374+ words) Nature Chemical Biology (2026)Cite this article Beuers, U. , Wolters, F. & Oude Elferink, R. P. J. Mechanisms of pruritus in cholestasis: understanding and treating the itch. Nat. Rev. Gastroenterol. Hepatol. 20, 2636 (2023). Vander Does, A. , Levy, C. & Yosipovitch, G. Cholestatic itch: our current understanding of pathophysiology and treatments. Am. J. Clin. Dermatol....
Lighting up lipid droplets - Nature Chemical Biology
5+ hour, 53+ min ago (201+ words) Nature Chemical Biology (2026)Cite this article Bersuker, K. et al. Dev. Cell 44, 97112. e7 (2018). Zhang, Y. et al. Nat. Catal. 8, 162177 (2025). Zhou, N. , Zhang, Y. , Chen, P. R. & Fan, X. Proc. Natl Acad. Sci. USA 122, e2503115122 (2025). Tamura, T. , Takato, M. , Shiono, K. & Hamachi, I. Chem. Lett. 49, 145148 (2020). Liu, Z. et al. Nat. Commun. 15, 2712 (2024). Lin, Z. et al. Science…...
From micromechanisms to macro-engineering in direct seawater electrolysis - Nature Reviews Clean Technology
2+ hour, 4+ min ago (1668+ words) Nature Reviews Clean Technology (2026)Cite this article With the annual additional installed capacity of the offshore wind market projected to reach approximately 40 GW by 2030, direct seawater electrolysis provides a potential alternative for offshore power conversion. Catalyst engineering has achieved a…...
Gene therapy for cardiac and vascular disease
3+ hour, 6+ min ago (154+ words) Nature Thank you for visiting nature. com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet…...
Recruiting without destroying - Nature Chemical Biology
12+ hour, 33+ min ago (160+ words) Nature Chemical Biology (2026)Cite this article Molecular glues offer a promising avenue for novel therapeutic development. The discovery of CLEO4-88 reveals a non-degradative molecular glue that promotes interaction between the CTLH substrate receptor GID4 and the peroxisomal thiolase ACAA1, inhibiting the enzymatic activity…...
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